Browsing by Author "Lambert, P. F."
Now showing items 1-6 of 6
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Deficiencies in the Fanconi Anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer
Park, J. W.; Pitot, H. C.; Strati, Katerina; Spardy, N.; Duensing, S.; Grompe, M.; Lambert, P. F. (2010)Patients with the rare genetic disease, Fanconi anemia (FA), are highly susceptible to squamous cell carcinomas arising at multiple anatomic sites including the head and neck region. Human papillomaviruses (HPVs), particularly ...
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Article
The HPV16 oncogenes cause aberrant stem cell mobilization
Michael, S.; Lambert, P. F.; Strati, Katerina (2013)Human Papilloma Virus related epithelial cancers have been speculated to derive from virus-infected tissue stem cells. Stem cells also are thought to provide a reservoir of latently infected cells that can persist for long ...
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Article
Human papillomavirus association with head and neck cancers: Understanding virus biology and using it in the development of cancer diagnostics
Strati, Katerina; Lambert, P. F. (2008)The link between human papillomaviruses (HPVs) and human cervical cancers has long been established. However, HPVs are now being detected in another type of cancer not previously associated with this virus, head and neck ...
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Article
Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in mice
Jabbar, S.; Strati, Katerina; Shin, M. K.; Pitot, H. C.; Lambert, P. F. (2010)High-risk human papillomaviruses (HPVs) contribute to cervical and other anogenital cancers, and they are also linked etiologically to a subset of head and neck squamous cell carcinomas (HNSCC). We previously established ...
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Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model
Strati, Katerina; Pitot, H. C.; Lambert, P. F. (2006)Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer mortality worldwide. Recent reports have associated a subset of HNSCC with high-risk human papillomaviruses (HPVs), particularly HPV16, the same ...
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Article
Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer
Strati, Katerina; Lambert, P. F. (2007)Infection with high-risk human papillomaviruses (HPV) and in particular the expression of the viral proteins E6 and E7 have been associated with the etiology of a subset of head and neck squamous cell cancer (HNSCC). ...